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A Leprostatic agent is a drug that interferes with proliferation of the bacterium that causes leprosy.〔(Definition: leprostatic from Online Medical Dictionary )〕 The following agents are leprostatic agents: * acedapsone * clofazimine * dapsone * desoxyfructo-serotonin * diucifon * ethionamide * rifampicin * rifapentine * sulfameter * thalidomide Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Host defenses are crucial in determining the patient’s response to the disease, the clinical presentation, and the bacillary load. These factors also influence the length of therapy and the risk of adverse reactions to medication. M. leprae cannot be grown on routine laboratory culture media, so drug sensitivity testing in vitro is not possible. Growth and drug susceptibility testing are done by injecting into animal models. One description of a clinical picture that results from tuberculoid leprosy is characterized by intact cell-mediated immunity, a positive lepromin skin reaction, granuloma formation, and a relative paucity of bacilli. At the other extreme, lepromatous leprosy is characterized by depressed cell-mediated immunity, numerous bacilli within the tissues, no granulomas, and a negative skin test for lepromin. Within these two extremes are the patients with an intermediate or borderline form of leprosy who show a variable lepromin reaction and few bacilli; they may progress to either tuberculoid or lepromatous leprosy. ==Kinds of antileprotic drugs== * Sulfone - Dapsone (DDS), * Phenazine derivative - Clofazimine, * Antitubercular drugs - Rifampicin, Ethionamide, * Solapsone, * Other antibiotics - Oflaxacin, Minocycline, Clarithromycin, Current recommendations for the treatment of leprosy suggest multidrug regimens rather than monotherapy because such a regimen has proven to be more effective, delays the emergence of resistance, prevents relapse, and shortens the duration of therapy. Established agents used in the treatment of leprosy are dapsone, clofazimine, and rifampicin. Treatment of tuberculoid leprosy is continued for at least 1 to 2 years, while patients with lepromatous leprosy are generally treated for 5 years. In addition to chemotherapy, patients with leprosy need psychosocial support, rehabilitation, and surgical repair of any disfiguration. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Leprostatic agent」の詳細全文を読む スポンサード リンク
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